There is no set answer as to how long the drug called Prednisone will remain in your system. The length of time varies according to each individual and is affected by many different factors. However, Prednisone can remain in your system for as long as two to three weeks. It is also important to note that it can take your body at least 6 months, or sometimes even longer, to completely reregulate itself after taking Prednisone.


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